Differences in the Selection Bottleneck between Modes of Sexual Transmission Influence the Genetic Composition of the HIV-1 Founder Virus

Differences in the Selection Bottleneck between Modes of Sexual Transmission Influence the Genetic Composition of the HIV-1 Founder Virus

Due to the stringent population bottleneck that occurs during sexual HIV-1 transmission, systemic infection is typically established by a limited number of founder viruses. Elucidation of the precise forces influencing the selection of founder viruses may reveal key vulnerabilities that could aid in...

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Bibliographic Details
Main Authors: Tully, Damien C., Ogilvie, Colin B., Batorsky, Rebecca E., Bean, David J., Power, Karen A., Ghebremichael, Musie, Bedard, Hunter E., Gladden, Adrianne D., Seese, Aaron M., Amero, Molly A., Lane, Kimberly, McGrath, Graham, Bazner, Suzane B., Tinsley, Jake, Lennon, Niall J., Henn, Matthew R., Brumme, Zabrina L., Norris, Philip J., Rosenberg, Eric S., Mayer, Kenneth H., Jessen, Heiko, Kosakovsky Pond, Sergei L., Walker, Bruce D., Altfeld, Marcus, Carlson, Jonathan M., Allen, Todd M.
Format: Online
Language:English
Published: Public Library of Science 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862634/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862634/

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