Bidirectional Association between Diabetes and Gout: the Singapore Chinese Health Study

We aimed to prospectively investigate the bidirectional association between type 2 diabetes (T2D) and gout. We analyzed follow-up data from the Singapore Chinese Health Study, when self-reports of diagnosed diabetes and gout were enquired at follow-ups I and II. Individuals who participated in both...

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Main Authors:	Pan, An, Teng, Gim Gee, Yuan, Jian-Min, Koh, Woon-Puay
Format:	Online
Language:	English
Published:	Nature Publishing Group 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861921/

id	pubmed-4861921
recordtype	oai_dc
spelling	pubmed-48619212016-05-20 Bidirectional Association between Diabetes and Gout: the Singapore Chinese Health Study Pan, An Teng, Gim Gee Yuan, Jian-Min Koh, Woon-Puay Article We aimed to prospectively investigate the bidirectional association between type 2 diabetes (T2D) and gout. We analyzed follow-up data from the Singapore Chinese Health Study, when self-reports of diagnosed diabetes and gout were enquired at follow-ups I and II. Individuals who participated in both follow-ups and were free of cardiovascular disease or cancer at follow-up I were included. For T2D to gout (analysis I), prevalent gout were further excluded (final n = 31,137). For gout to T2D (analysis II), prevalent diabetes were excluded (final n = 28,668). Cox regression models were used to estimate relative risks (RRs). In the analysis I, the RR of diabetes to incident gout (682 cases) was 0.77 (95% CI 0.60–0.97). In the analysis II, the RR of gout to incident diabetes (2223 cases) was 1.36 (1.12–1.63), but became insignificant after adjustment for hypertension and BMI (1.00; 0.83–1.21). The gout to diabetes association was modified by BMI (Pinteraction = 0.04) and hypertension (Pinteraction = 0.007), and it was marginally significant in adults with BMI<24 while significant among non-hypertensive participants, but not in their counterparts. In conclusion, our results suggest that diabetes is associated with a lower risk of incident gout, while gout is positively related to diabetes among normal weight and non-hypertensive adults. Nature Publishing Group 2016-05-10 /pmc/articles/PMC4861921/ /pubmed/27161168 http://dx.doi.org/10.1038/srep25766 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Pan, An Teng, Gim Gee Yuan, Jian-Min Koh, Woon-Puay
spellingShingle	Pan, An Teng, Gim Gee Yuan, Jian-Min Koh, Woon-Puay Bidirectional Association between Diabetes and Gout: the Singapore Chinese Health Study
author_facet	Pan, An Teng, Gim Gee Yuan, Jian-Min Koh, Woon-Puay
author_sort	Pan, An
title	Bidirectional Association between Diabetes and Gout: the Singapore Chinese Health Study
title_short	Bidirectional Association between Diabetes and Gout: the Singapore Chinese Health Study
title_full	Bidirectional Association between Diabetes and Gout: the Singapore Chinese Health Study
title_fullStr	Bidirectional Association between Diabetes and Gout: the Singapore Chinese Health Study
title_full_unstemmed	Bidirectional Association between Diabetes and Gout: the Singapore Chinese Health Study
title_sort	bidirectional association between diabetes and gout: the singapore chinese health study
description	We aimed to prospectively investigate the bidirectional association between type 2 diabetes (T2D) and gout. We analyzed follow-up data from the Singapore Chinese Health Study, when self-reports of diagnosed diabetes and gout were enquired at follow-ups I and II. Individuals who participated in both follow-ups and were free of cardiovascular disease or cancer at follow-up I were included. For T2D to gout (analysis I), prevalent gout were further excluded (final n = 31,137). For gout to T2D (analysis II), prevalent diabetes were excluded (final n = 28,668). Cox regression models were used to estimate relative risks (RRs). In the analysis I, the RR of diabetes to incident gout (682 cases) was 0.77 (95% CI 0.60–0.97). In the analysis II, the RR of gout to incident diabetes (2223 cases) was 1.36 (1.12–1.63), but became insignificant after adjustment for hypertension and BMI (1.00; 0.83–1.21). The gout to diabetes association was modified by BMI (Pinteraction = 0.04) and hypertension (Pinteraction = 0.007), and it was marginally significant in adults with BMI<24 while significant among non-hypertensive participants, but not in their counterparts. In conclusion, our results suggest that diabetes is associated with a lower risk of incident gout, while gout is positively related to diabetes among normal weight and non-hypertensive adults.
publisher	Nature Publishing Group
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861921/
_version_	1613577410468380672

Bidirectional Association between Diabetes and Gout: the Singapore Chinese Health Study

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