UV-induced inhibition of adipokine production in subcutaneous fat aggravates dermal matrix degradation in human skin
Ultraviolet (UV) exposure to the human skin reduces triglycerides contents and lipid synthesis in the subcutaneous (SC) fat. Because adiponectin and leptin are the most abundant adipokines from the SC fat, we aim to investigate how they interact with UV exposure and skin aging. The expressions of ad...
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Nature Publishing Group
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861907/ |
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pubmed-48619072016-05-20 UV-induced inhibition of adipokine production in subcutaneous fat aggravates dermal matrix degradation in human skin Kim, Eun Ju Kim, Yeon Kyung Kim, Min-Kyoung Kim, Sungsoo Kim, Jin Yong Lee, Dong Hun Chung, Jin Ho Article Ultraviolet (UV) exposure to the human skin reduces triglycerides contents and lipid synthesis in the subcutaneous (SC) fat. Because adiponectin and leptin are the most abundant adipokines from the SC fat, we aim to investigate how they interact with UV exposure and skin aging. The expressions of adiponectin and leptin were significantly decreased in SC fat of sun-exposed forearm skin, in comparison with that of sun-protected buttock skin of the same elderly individuals, indicating that chronic UV exposure decreases both adipokines. Acute UV irradiation also decreased the expressions of adiponectin and leptin in SC fat. The expressions of adiponectin receptor 1/2 and leptin receptor were significantly decreased in the dermis as well as in SC fat. Moreover, while exogenous adiponectin and leptin administration prevented UV- and TNF-α induced matrix metalloproteinase (MMP)-1 expression, they also increased UV- and TNF-α induced reduction of type 1 procollagen production. Silencing of adiponectin, leptin or their receptors led to an increased MMP-1 and a decreased type 1 procollagen expression, which was reversed by treatment with recombinant human adiponectin or leptin. In conclusion, UV exposure decreases the expression of adiponectin and leptin, leading to the exacerbation of photoaging by stimulating MMP-1 expression and inhibiting procollagen synthesis. Nature Publishing Group 2016-05-10 /pmc/articles/PMC4861907/ /pubmed/27161953 http://dx.doi.org/10.1038/srep25616 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Kim, Eun Ju Kim, Yeon Kyung Kim, Min-Kyoung Kim, Sungsoo Kim, Jin Yong Lee, Dong Hun Chung, Jin Ho |
| spellingShingle |
Kim, Eun Ju Kim, Yeon Kyung Kim, Min-Kyoung Kim, Sungsoo Kim, Jin Yong Lee, Dong Hun Chung, Jin Ho UV-induced inhibition of adipokine production in subcutaneous fat aggravates dermal matrix degradation in human skin |
| author_facet |
Kim, Eun Ju Kim, Yeon Kyung Kim, Min-Kyoung Kim, Sungsoo Kim, Jin Yong Lee, Dong Hun Chung, Jin Ho |
| author_sort |
Kim, Eun Ju |
| title |
UV-induced inhibition of adipokine production in subcutaneous fat aggravates dermal matrix degradation in human skin |
| title_short |
UV-induced inhibition of adipokine production in subcutaneous fat aggravates dermal matrix degradation in human skin |
| title_full |
UV-induced inhibition of adipokine production in subcutaneous fat aggravates dermal matrix degradation in human skin |
| title_fullStr |
UV-induced inhibition of adipokine production in subcutaneous fat aggravates dermal matrix degradation in human skin |
| title_full_unstemmed |
UV-induced inhibition of adipokine production in subcutaneous fat aggravates dermal matrix degradation in human skin |
| title_sort |
uv-induced inhibition of adipokine production in subcutaneous fat aggravates dermal matrix degradation in human skin |
| description |
Ultraviolet (UV) exposure to the human skin reduces triglycerides contents and lipid synthesis in the subcutaneous (SC) fat. Because adiponectin and leptin are the most abundant adipokines from the SC fat, we aim to investigate how they interact with UV exposure and skin aging. The expressions of adiponectin and leptin were significantly decreased in SC fat of sun-exposed forearm skin, in comparison with that of sun-protected buttock skin of the same elderly individuals, indicating that chronic UV exposure decreases both adipokines. Acute UV irradiation also decreased the expressions of adiponectin and leptin in SC fat. The expressions of adiponectin receptor 1/2 and leptin receptor were significantly decreased in the dermis as well as in SC fat. Moreover, while exogenous adiponectin and leptin administration prevented UV- and TNF-α induced matrix metalloproteinase (MMP)-1 expression, they also increased UV- and TNF-α induced reduction of type 1 procollagen production. Silencing of adiponectin, leptin or their receptors led to an increased MMP-1 and a decreased type 1 procollagen expression, which was reversed by treatment with recombinant human adiponectin or leptin. In conclusion, UV exposure decreases the expression of adiponectin and leptin, leading to the exacerbation of photoaging by stimulating MMP-1 expression and inhibiting procollagen synthesis. |
| publisher |
Nature Publishing Group |
| publishDate |
2016 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861907/ |
| _version_ |
1613577401834405888 |