| Summary: | Bullous leukemia cutis is an uncommon clinical manifestation of cutaneous
infiltration by leukemic cells, from B-cell chronic lymphocytic leukemia. We
present the case of a 67-year-old, female, chronic lymphocytic leukemia patient.
She was taking chlorambucil and developed facial edema with erythema and warmth,
misjudged as facial cellulitis. Two days later, she developed bullous lesions in
the arms, legs, neck and face. The histopathology of facial and bullous lesions
confirmed leukemia cutis. All lesions disappeared following the administration
of rituximab combined with cycles of fludarabine and cyclophosphamide. Although
soft tissue infections are common complications in patients undergoing
chemotherapy, leukemia cutis can also resemble cellulitis.
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