Acinar phenotype is preserved in human exocrine pancreas cells cultured at low temperature: implications for lineage-tracing of β-cell neogenesis

In vitro cultured pancreatic acinar cells rapidly differentiate. Low temperature exposure prevents this process and improves the efficiency of acinar cell labelling with adenovirus vectors. This may help in tracing β-cell neogenesis from human pancreatic acinar cells.

Bibliographic Details
Main Authors: Mfopou, Josué K., Houbracken, Isabelle, Wauters, Elke, Mathijs, Iris, Song, Imane, Himpe, Eddy, Baldan, Jonathan, Heimberg, Harry, Bouwens, Luc
Format: Online
Language:English
Published: Portland Press Ltd. 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4859086/