Structure of a HOIP/E2~ubiquitin complex reveals RBR E3 ligase mechanism and regulation
Ubiquitination is a central process affecting all facets of cellular signaling and function1. A critical step in ubiquitination is the transfer of ubiquitin from an E2 ubiquitin-conjugating enzyme to a substrate or a growing ubiquitin chain, which is mediated by E3 ubiquitin ligases. RING-type E3 li...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
2016
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856479/ |