Small molecules that allosterically inhibit p21-activated kinase activity by binding to the regulatory p21-binding domain

Small molecules that allosterically inhibit p21-activated kinase activity by binding to the regulatory p21-binding domain

p21-activated kinases (PAKs) are key regulators of actin dynamics, cell proliferation and cell survival. Deregulation of PAK activity contributes to the pathogenesis of various human diseases, including cancer and neurological disorders. Using an ELISA-based screening protocol, we identified naphtho...

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Bibliographic Details
Main Authors: Kim, Duk-Joong, Choi, Chang-Ki, Lee, Chan-Soo, Park, Mee-Hee, Tian, Xizhe, Kim, Nam Doo, Lee, Kee-In, Choi, Joong-Kwon, Ahn, Jin Hee, Shin, Eun-Young, Shin, Injae, Kim, Eung-Gook
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855275/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855275/

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