Activation of the EIF2AK4-EIF2A/eIF2α-ATF4 pathway triggers autophagy response to Crohn disease-associated adherent-invasive Escherichia coli infection

Activation of the EIF2AK4-EIF2A/eIF2α-ATF4 pathway triggers autophagy response to Crohn disease-associated adherent-invasive Escherichia coli infection

The intestinal mucosa of Crohn disease (CD) patients is abnormally colonized by adherent-invasive E. coli (AIEC). Upon AIEC infection, autophagy is induced in host cells to restrain bacterial intracellular replication. The underlying mechanism, however, remains unknown. Here, we investigated the rol...

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Bibliographic Details
Main Authors: Bretin, Alexis, Carrière, Jessica, Dalmasso, Guillaume, Bergougnoux, Agnès, B'chir, Wafa, Maurin, Anne-Catherine, Müller, Stefan, Seibold, Frank, Barnich, Nicolas, Bruhat, Alain, Darfeuille-Michaud, Arlette, Nguyen, Hang Thi Thu
Format: Online
Language:English
Published: Taylor & Francis 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854551/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854551/

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