Transcriptional Regulation of Heart Development in Zebrafish
Cardiac transcription factors orchestrate the complex cellular and molecular events required to produce a functioning heart. Misregulation of the cardiac transcription program leads to embryonic developmental defects and is associated with human congenital heart diseases. Recent studies have expande...
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| Format: | Online |
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MDPI
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852312/ |
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pubmed-48523122016-05-02 Transcriptional Regulation of Heart Development in Zebrafish Lu, Fei Langenbacher, Adam D. Chen, Jau-Nian Review Cardiac transcription factors orchestrate the complex cellular and molecular events required to produce a functioning heart. Misregulation of the cardiac transcription program leads to embryonic developmental defects and is associated with human congenital heart diseases. Recent studies have expanded our understanding of the regulation of cardiac gene expression at an additional layer, involving the coordination of epigenetic and transcriptional regulators. In this review, we highlight and discuss discoveries made possible by the genetic and embryological tools available in the zebrafish model organism, with a focus on the novel functions of cardiac transcription factors and epigenetic and transcriptional regulatory proteins during cardiogenesis. MDPI 2016-04-09 /pmc/articles/PMC4852312/ /pubmed/27148546 http://dx.doi.org/10.3390/jcdd3020014 Text en © 2016 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Lu, Fei Langenbacher, Adam D. Chen, Jau-Nian |
| spellingShingle |
Lu, Fei Langenbacher, Adam D. Chen, Jau-Nian Transcriptional Regulation of Heart Development in Zebrafish |
| author_facet |
Lu, Fei Langenbacher, Adam D. Chen, Jau-Nian |
| author_sort |
Lu, Fei |
| title |
Transcriptional Regulation of Heart Development in Zebrafish |
| title_short |
Transcriptional Regulation of Heart Development in Zebrafish |
| title_full |
Transcriptional Regulation of Heart Development in Zebrafish |
| title_fullStr |
Transcriptional Regulation of Heart Development in Zebrafish |
| title_full_unstemmed |
Transcriptional Regulation of Heart Development in Zebrafish |
| title_sort |
transcriptional regulation of heart development in zebrafish |
| description |
Cardiac transcription factors orchestrate the complex cellular and molecular events required to produce a functioning heart. Misregulation of the cardiac transcription program leads to embryonic developmental defects and is associated with human congenital heart diseases. Recent studies have expanded our understanding of the regulation of cardiac gene expression at an additional layer, involving the coordination of epigenetic and transcriptional regulators. In this review, we highlight and discuss discoveries made possible by the genetic and embryological tools available in the zebrafish model organism, with a focus on the novel functions of cardiac transcription factors and epigenetic and transcriptional regulatory proteins during cardiogenesis. |
| publisher |
MDPI |
| publishDate |
2016 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852312/ |
| _version_ |
1613573768102281216 |