Merozoite surface proteins in red blood cell invasion, immunity and vaccines against malaria

Malaria accounts for an enormous burden of disease globally, with Plasmodium falciparum accounting for the majority of malaria, and P. vivax being a second important cause, especially in Asia, the Americas and the Pacific. During infection with Plasmodium spp., the merozoite form of the parasite inv...

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Main Authors:	Beeson, James G., Drew, Damien R., Boyle, Michelle J., Feng, Gaoqian, Fowkes, Freya J.I., Richards, Jack S.
Format:	Online
Language:	English
Published:	Oxford University Press 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852283/

id	pubmed-4852283
recordtype	oai_dc
spelling	pubmed-48522832016-05-03 Merozoite surface proteins in red blood cell invasion, immunity and vaccines against malaria Beeson, James G. Drew, Damien R. Boyle, Michelle J. Feng, Gaoqian Fowkes, Freya J.I. Richards, Jack S. Review Article Malaria accounts for an enormous burden of disease globally, with Plasmodium falciparum accounting for the majority of malaria, and P. vivax being a second important cause, especially in Asia, the Americas and the Pacific. During infection with Plasmodium spp., the merozoite form of the parasite invades red blood cells and replicates inside them. It is during the blood-stage of infection that malaria disease occurs and, therefore, understanding merozoite invasion, host immune responses to merozoite surface antigens, and targeting merozoite surface proteins and invasion ligands by novel vaccines and therapeutics have been important areas of research. Merozoite invasion involves multiple interactions and events, and substantial processing of merozoite surface proteins occurs before, during and after invasion. The merozoite surface is highly complex, presenting a multitude of antigens to the immune system. This complexity has proved challenging to our efforts to understand merozoite invasion and malaria immunity, and to developing merozoite antigens as malaria vaccines. In recent years, there has been major progress in this field, and several merozoite surface proteins show strong potential as malaria vaccines. Our current knowledge on this topic is reviewed, highlighting recent advances and research priorities. Oxford University Press 2016-02-01 2016-05-01 /pmc/articles/PMC4852283/ /pubmed/26833236 http://dx.doi.org/10.1093/femsre/fuw001 Text en © FEMS 2016. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Beeson, James G. Drew, Damien R. Boyle, Michelle J. Feng, Gaoqian Fowkes, Freya J.I. Richards, Jack S.
spellingShingle	Beeson, James G. Drew, Damien R. Boyle, Michelle J. Feng, Gaoqian Fowkes, Freya J.I. Richards, Jack S. Merozoite surface proteins in red blood cell invasion, immunity and vaccines against malaria
author_facet	Beeson, James G. Drew, Damien R. Boyle, Michelle J. Feng, Gaoqian Fowkes, Freya J.I. Richards, Jack S.
author_sort	Beeson, James G.
title	Merozoite surface proteins in red blood cell invasion, immunity and vaccines against malaria
title_short	Merozoite surface proteins in red blood cell invasion, immunity and vaccines against malaria
title_full	Merozoite surface proteins in red blood cell invasion, immunity and vaccines against malaria
title_fullStr	Merozoite surface proteins in red blood cell invasion, immunity and vaccines against malaria
title_full_unstemmed	Merozoite surface proteins in red blood cell invasion, immunity and vaccines against malaria
title_sort	merozoite surface proteins in red blood cell invasion, immunity and vaccines against malaria
description	Malaria accounts for an enormous burden of disease globally, with Plasmodium falciparum accounting for the majority of malaria, and P. vivax being a second important cause, especially in Asia, the Americas and the Pacific. During infection with Plasmodium spp., the merozoite form of the parasite invades red blood cells and replicates inside them. It is during the blood-stage of infection that malaria disease occurs and, therefore, understanding merozoite invasion, host immune responses to merozoite surface antigens, and targeting merozoite surface proteins and invasion ligands by novel vaccines and therapeutics have been important areas of research. Merozoite invasion involves multiple interactions and events, and substantial processing of merozoite surface proteins occurs before, during and after invasion. The merozoite surface is highly complex, presenting a multitude of antigens to the immune system. This complexity has proved challenging to our efforts to understand merozoite invasion and malaria immunity, and to developing merozoite antigens as malaria vaccines. In recent years, there has been major progress in this field, and several merozoite surface proteins show strong potential as malaria vaccines. Our current knowledge on this topic is reviewed, highlighting recent advances and research priorities.
publisher	Oxford University Press
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852283/
_version_	1613573754962575360

Merozoite surface proteins in red blood cell invasion, immunity and vaccines against malaria

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