Sterile inflammation induced by Carbopol elicits robust adaptive immune responses in the absence of pathogen-associated molecular patterns

Sterile inflammation induced by Carbopol elicits robust adaptive immune responses in the absence of pathogen-associated molecular patterns

•Carbopol induces Th1/IgG2a responses without PRR activation.•Carbopol polymer morphology is changed by APC phagocytosis leading to ROS induction.•This study highlights a potentially novel mechanism for in vivo cellular activation.

Bibliographic Details
Main Authors: Gartlan, Kate H., Krashias, George, Wegmann, Frank, Hillson, William R., Scherer, Erin M., Greenberg, Philip D., Eisenbarth, Stephanie C., Moghaddam, Amin E., Sattentau, Quentin J.
Format: Online
Language:English
Published: Elsevier Science 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850248/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850248/

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