In Vitro Model for Hepatotoxicity Studies Based on Primary Human Hepatocyte Cultivation in a Perfused 3D Bioreactor System

In Vitro Model for Hepatotoxicity Studies Based on Primary Human Hepatocyte Cultivation in a Perfused 3D Bioreactor System

Accurate prediction of the potential hepatotoxic nature of new pharmaceuticals remains highly challenging. Therefore, novel in vitro models with improved external validity are needed to investigate hepatic metabolism and timely identify any toxicity of drugs in humans. In this study, we examined the...

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Main Authors: Knöspel, Fanny, Jacobs, Frank, Freyer, Nora, Damm, Georg, De Bondt, An, van den Wyngaert, Ilse, Snoeys, Jan, Monshouwer, Mario, Richter, Marco, Strahl, Nadja, Seehofer, Daniel, Zeilinger, Katrin
Format: Online
Language:English
Published: MDPI 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849040/

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