Current Approaches for Diagnosis of Influenza Virus Infections in Humans

Current Approaches for Diagnosis of Influenza Virus Infections in Humans

Despite significant advancement in vaccine and virus research, influenza continues to be a major public health concern. Each year in the United States of America, influenza viruses are responsible for seasonal epidemics resulting in over 200,000 hospitalizations and 30,000–50,000 deaths. Accurate an...

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Main Authors: Vemula, Sai Vikram, Zhao, Jiangqin, Liu, Jikun, Wang, Xue, Biswas, Santanu, Hewlett, Indira
Format: Online
Language:English
Published: MDPI 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848591/
id pubmed-4848591
recordtype oai_dc
spelling pubmed-48485912016-05-04 Current Approaches for Diagnosis of Influenza Virus Infections in Humans Vemula, Sai Vikram Zhao, Jiangqin Liu, Jikun Wang, Xue Biswas, Santanu Hewlett, Indira Review Despite significant advancement in vaccine and virus research, influenza continues to be a major public health concern. Each year in the United States of America, influenza viruses are responsible for seasonal epidemics resulting in over 200,000 hospitalizations and 30,000–50,000 deaths. Accurate and early diagnosis of influenza viral infections are critical for rapid initiation of antiviral therapy to reduce influenza related morbidity and mortality both during seasonal epidemics and pandemics. Several different approaches are currently available for diagnosis of influenza infections in humans. These include viral isolation in cell culture, immunofluorescence assays, nucleic acid amplification tests, immunochromatography-based rapid diagnostic tests, etc. Newer diagnostic approaches are being developed to overcome the limitations associated with some of the conventional detection methods. This review discusses diagnostic approaches currently available for detection of influenza viruses in humans. MDPI 2016-04-12 /pmc/articles/PMC4848591/ /pubmed/27077877 http://dx.doi.org/10.3390/v8040096 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Vemula, Sai Vikram
Zhao, Jiangqin
Liu, Jikun
Wang, Xue
Biswas, Santanu
Hewlett, Indira
spellingShingle Vemula, Sai Vikram
Zhao, Jiangqin
Liu, Jikun
Wang, Xue
Biswas, Santanu
Hewlett, Indira
Current Approaches for Diagnosis of Influenza Virus Infections in Humans
author_facet Vemula, Sai Vikram
Zhao, Jiangqin
Liu, Jikun
Wang, Xue
Biswas, Santanu
Hewlett, Indira
author_sort Vemula, Sai Vikram
title Current Approaches for Diagnosis of Influenza Virus Infections in Humans
title_short Current Approaches for Diagnosis of Influenza Virus Infections in Humans
title_full Current Approaches for Diagnosis of Influenza Virus Infections in Humans
title_fullStr Current Approaches for Diagnosis of Influenza Virus Infections in Humans
title_full_unstemmed Current Approaches for Diagnosis of Influenza Virus Infections in Humans
title_sort current approaches for diagnosis of influenza virus infections in humans
description Despite significant advancement in vaccine and virus research, influenza continues to be a major public health concern. Each year in the United States of America, influenza viruses are responsible for seasonal epidemics resulting in over 200,000 hospitalizations and 30,000–50,000 deaths. Accurate and early diagnosis of influenza viral infections are critical for rapid initiation of antiviral therapy to reduce influenza related morbidity and mortality both during seasonal epidemics and pandemics. Several different approaches are currently available for diagnosis of influenza infections in humans. These include viral isolation in cell culture, immunofluorescence assays, nucleic acid amplification tests, immunochromatography-based rapid diagnostic tests, etc. Newer diagnostic approaches are being developed to overcome the limitations associated with some of the conventional detection methods. This review discusses diagnostic approaches currently available for detection of influenza viruses in humans.
publisher MDPI
publishDate 2016
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848591/
_version_ 1613572302318862336

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