Sleeping Beauty transposon screen identifies signaling modules that cooperate with STAT5 activation to induce B cell acute lymphoblastic leukemia

Sleeping Beauty transposon screen identifies signaling modules that cooperate with STAT5 activation to induce B cell acute lymphoblastic leukemia

STAT5 activation occurs frequently in human progenitor B cell acute lymphoblastic leukemia (B-ALL). To identify gene alterations that cooperate with STAT5 activation to initiate leukemia we crossed mice expressing a constitutively active form of STAT5 (Stat5b-CA) to mice in which a mutagenic Sleepin...

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Bibliographic Details
Main Authors: Heltemes-Harris, Lynn M., Larson, Jon D., Starr, Timothy K., Hubbard, Gregory K., Sarver, Aaron L., Largaespada, David A., Farrar, Michael A.
Format: Online
Language:English
Published: 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846597/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846597/

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