Metadherin regulates epithelial–mesenchymal transition in carcinoma

Metadherin (MTDH) was first identified in primary human fetal astrocytes exposed to HIV-1 in 2002 and then recognized as an important oncogene mediating tumorigenesis, progression, invasiveness, and metastasis of carcinomas. Epithelial–mesenchymal transition (EMT) is a vital process in embryonic dev...

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Main Authors:	Wang, Zhao, Tang, Zheng-yan, Yin, Zhuo, Wei, Yong-bao, Liu, Long-fei, Yan, Bin, Zhou, Ke-qin, Nian, Ye-qi, Gao, Yun-liang, Yang, Jin-rui
Format:	Online
Language:	English
Published:	Dove Medical Press 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844438/

id	pubmed-4844438
recordtype	oai_dc
spelling	pubmed-48444382016-05-03 Metadherin regulates epithelial–mesenchymal transition in carcinoma Wang, Zhao Tang, Zheng-yan Yin, Zhuo Wei, Yong-bao Liu, Long-fei Yan, Bin Zhou, Ke-qin Nian, Ye-qi Gao, Yun-liang Yang, Jin-rui Review Metadherin (MTDH) was first identified in primary human fetal astrocytes exposed to HIV-1 in 2002 and then recognized as an important oncogene mediating tumorigenesis, progression, invasiveness, and metastasis of carcinomas. Epithelial–mesenchymal transition (EMT) is a vital process in embryonic development, organ repair, and cancer progression. MTDH and EMT have also been proved to be related to the prognosis of patients with cancers. Recent studies reveal a relationship between MTDH overexpression and EMT in some malignancies. This review highlights the overexpression of MTDH and EMT in cancers and their correlations in clinical studies. Positive correlations have been established between MTDH and mesenchymal biomarkers, and negative correlations between MTDH and epithelial biomarkers have also been established. Furthermore, experiments reveal EMT regulated by MTDH, and some signal pathways have been established. Some anticancer drugs targeting MTDH and EMT are introduced in this review. Some perspectives concerning EMT regulation by MTDH are also presented in this review. Dove Medical Press 2016-04-21 /pmc/articles/PMC4844438/ /pubmed/27143938 http://dx.doi.org/10.2147/OTT.S104556 Text en © 2016 Wang et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Wang, Zhao Tang, Zheng-yan Yin, Zhuo Wei, Yong-bao Liu, Long-fei Yan, Bin Zhou, Ke-qin Nian, Ye-qi Gao, Yun-liang Yang, Jin-rui
spellingShingle	Wang, Zhao Tang, Zheng-yan Yin, Zhuo Wei, Yong-bao Liu, Long-fei Yan, Bin Zhou, Ke-qin Nian, Ye-qi Gao, Yun-liang Yang, Jin-rui Metadherin regulates epithelial–mesenchymal transition in carcinoma
author_facet	Wang, Zhao Tang, Zheng-yan Yin, Zhuo Wei, Yong-bao Liu, Long-fei Yan, Bin Zhou, Ke-qin Nian, Ye-qi Gao, Yun-liang Yang, Jin-rui
author_sort	Wang, Zhao
title	Metadherin regulates epithelial–mesenchymal transition in carcinoma
title_short	Metadherin regulates epithelial–mesenchymal transition in carcinoma
title_full	Metadherin regulates epithelial–mesenchymal transition in carcinoma
title_fullStr	Metadherin regulates epithelial–mesenchymal transition in carcinoma
title_full_unstemmed	Metadherin regulates epithelial–mesenchymal transition in carcinoma
title_sort	metadherin regulates epithelial–mesenchymal transition in carcinoma
description	Metadherin (MTDH) was first identified in primary human fetal astrocytes exposed to HIV-1 in 2002 and then recognized as an important oncogene mediating tumorigenesis, progression, invasiveness, and metastasis of carcinomas. Epithelial–mesenchymal transition (EMT) is a vital process in embryonic development, organ repair, and cancer progression. MTDH and EMT have also been proved to be related to the prognosis of patients with cancers. Recent studies reveal a relationship between MTDH overexpression and EMT in some malignancies. This review highlights the overexpression of MTDH and EMT in cancers and their correlations in clinical studies. Positive correlations have been established between MTDH and mesenchymal biomarkers, and negative correlations between MTDH and epithelial biomarkers have also been established. Furthermore, experiments reveal EMT regulated by MTDH, and some signal pathways have been established. Some anticancer drugs targeting MTDH and EMT are introduced in this review. Some perspectives concerning EMT regulation by MTDH are also presented in this review.
publisher	Dove Medical Press
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844438/
_version_	1613570693988876288

Metadherin regulates epithelial–mesenchymal transition in carcinoma

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