miR-3188 regulates nasopharyngeal carcinoma proliferation and chemosensitivity through a FOXO1-modulated positive feedback loop with mTOR–p-PI3K/AKT-c-JUN

miR-3188 regulates nasopharyngeal carcinoma proliferation and chemosensitivity through a FOXO1-modulated positive feedback loop with mTOR–p-PI3K/AKT-c-JUN

The biological role of miR-3188 has not yet been reported in the context of cancer. In this study, we observe that miR-3188 not only reduces cell-cycle transition and proliferation, but also significantly prolongs the survival time of tumour-bearing mice as well as sensitizes cells to 5-FU. Mechanis...

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Bibliographic Details
Main Authors: Zhao, Mengyang, Luo, Rongcheng, Liu, Yiyi, Gao, Linyuan, Fu, Zhaojian, Fu, Qiaofen, Luo, Xiaojun, Chen, Yiyu, Deng, Xiaojie, Liang, Zixi, Li, Xin, Cheng, Chao, Liu, Zhen, Fang, Weiyi
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4842991/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4842991/

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