Lineage conversion induced by pluripotency factors involves transient passage through an iPS cell stage
Brief expression of pluripotency-associated factors such as Oct4, Klf4, Sox2 and c-Myc (OKSM), in combination with differentiation-inducing signals, was reported to trigger transdifferentiation of fibroblasts into other cell types. Here we show that OKSM expression in mouse fibroblasts gives rise to...
Main Authors: | , , , , , , , , |
---|---|
Format: | Online |
Language: | English |
Published: |
2015
|
Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840929/ |