MDM2 Inhibition Sensitizes Prostate Cancer Cells to Androgen Ablation and Radiotherapy in a p53-Dependent Manner12

MDM2 Inhibition Sensitizes Prostate Cancer Cells to Androgen Ablation and Radiotherapy in a p53-Dependent Manner12

PURPOSE: Increased murine double minute 2 (MDM2) expression, independent of p53 status, is associated with increased cancer-specific mortality for men with prostate cancer treated with radiotherapy. We assessed MI-219, a small molecule inhibitor of MDM2 with improved pharmacokinetics over nutlin-3,...

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Bibliographic Details
Main Authors: Feng, Felix Y., Zhang, Yu, Kothari, Vishal, Evans, Joseph R., Jackson, William C., Chen, Wei, Johnson, Skyler B., Luczak, Connor, Wang, Shaomeng, Hamstra, Daniel A.
Format: Online
Language:English
Published: Neoplasia Press 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840291/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840291/

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