Dystrophin expression in muscle stem cells regulates their polarity and asymmetric division

Dystrophin is expressed in differentiated myofibers where it is required for sarcolemmal integrity, and loss-of-function mutations in its gene result in Duchenne Muscular Dystrophy (DMD), a disease characterized by progressive and severe skeletal muscle degeneration. Here we found that dystrophin is...

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Bibliographic Details
Main Authors: Dumont, Nicolas A., Wang, Yu Xin, von Maltzahn, Julia, Pasut, Alessandra, Bentzinger, C. Florian, Brun, Caroline E., Rudnicki, Michael A.
Format: Online
Language:English
Published: 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839960/