Bridge helix bending promotes RNA polymerase II backtracking through a critical and conserved threonine residue

Bridge helix bending promotes RNA polymerase II backtracking through a critical and conserved threonine residue

The dynamics of the RNA polymerase II (Pol II) backtracking process is poorly understood. We built a Markov State Model from extensive molecular dynamics simulations to identify metastable intermediate states and the dynamics of backtracking at atomistic detail. Our results reveal that Pol II backtr...

Full description

Bibliographic Details
Main Authors: Da, Lin-Tai, Pardo-Avila, Fátima, Xu, Liang, Silva, Daniel-Adriano, Zhang, Lu, Gao, Xin, Wang, Dong, Huang, Xuhui
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838855/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838855/

Similar Items