Autophagy-mediated longevity is modulated by lipoprotein biogenesis

Autophagy-dependent longevity models in C. elegans display altered lipid storage profiles, but the contribution of lipid distribution to life-span extension is not fully understood. Here we report that lipoprotein production, autophagy and lysosomal lipolysis are linked to modulate life span in a co...

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Bibliographic Details
Main Authors: Seah, Nicole E., de Magalhaes Filho, C. Daniel, Petrashen, Anna P., Henderson, Hope R., Laguer, Jade, Gonzalez, Julissa, Dillin, Andrew, Hansen, Malene, Lapierre, Louis R.
Format: Online
Language:English
Published: Taylor & Francis 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836030/