Harnessing publicly available genetic data to prioritize lipid modifying therapeutic targets for prevention of coronary heart disease based on dysglycemic risk

Harnessing publicly available genetic data to prioritize lipid modifying therapeutic targets for prevention of coronary heart disease based on dysglycemic risk

Therapeutic interventions that lower LDL-cholesterol effectively reduce the risk of coronary artery disease (CAD). However, statins, the most widely prescribed LDL-cholesterol lowering drugs, increase diabetes risk. We used genome-wide association study (GWAS) data in the public domain to investigat...

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Bibliographic Details
Main Authors: Tragante, Vinicius, Asselbergs, Folkert W., Swerdlow, Daniel I., Palmer, Tom M., Moore, Jason H., de Bakker, Paul I. W., Keating, Brendan J., Holmes, Michael V.
Format: Online
Language:English
Published: Springer Berlin Heidelberg 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835528/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835528/

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