An EWS-FLI1-Induced Osteosarcoma Model Unveiled a Crucial Role of Impaired Osteogenic Differentiation on Osteosarcoma Development

An EWS-FLI1-Induced Osteosarcoma Model Unveiled a Crucial Role of Impaired Osteogenic Differentiation on Osteosarcoma Development

EWS-FLI1, a multi-functional fusion oncogene, is exclusively detected in Ewing sarcomas. However, previous studies reported that rare varieties of osteosarcomas also harbor EWS-ETS family fusion. Here, using the doxycycline-inducible EWS-FLI1 system, we established an EWS-FLI1-dependent osteosarcoma...

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Bibliographic Details
Main Authors: Komura, Shingo, Semi, Katsunori, Itakura, Fumiaki, Shibata, Hirofumi, Ohno, Takatoshi, Hotta, Akitsu, Woltjen, Knut, Yamamoto, Takuya, Akiyama, Haruhiko, Yamada, Yasuhiro
Format: Online
Language:English
Published: Elsevier 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834047/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834047/

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