MicroRNA-15b regulates mitochondrial ROS production and the senescence-associated secretory phenotype through sirtuin 4/SIRT4

MicroRNA-15b regulates mitochondrial ROS production and the senescence-associated secretory phenotype through sirtuin 4/SIRT4

Mammalian sirtuins are involved in the control of metabolism and life-span regulation. Here, we link the mitochondrial sirtuin SIRT4 with cellular senescence, skin aging, and mitochondrial dysfunction. SIRT4 expression significantly increased in human dermal fibroblasts undergoing replicative or str...

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Bibliographic Details
Main Authors: Lang, Alexander, Grether-Beck, Susanne, Singh, Madhurendra, Kuck, Fabian, Jakob, Sascha, Kefalas, Andreas, Altinoluk-Hambüchen, Simone, Graffmann, Nina, Schneider, Maren, Lindecke, Antje, Brenden, Heidi, Felsner, Ingo, Ezzahoini, Hakima, Marini, Alessandra, Weinhold, Sandra, Vierkötter, Andrea, Tigges, Julia, Schmidt, Stephan, Stühler, Kai, Köhrer, Karl, Uhrberg, Markus, Haendeler, Judith, Krutmann, Jean, Piekorz, Roland P.
Format: Online
Language:English
Published: Impact Journals LLC 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833141/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833141/

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