Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3

Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3

Lymphangiogenesis plays a pivotal role in diverse pathological conditions. Here, we demonstrate that a carbohydrate-binding protein, galectin-8, promotes pathological lymphangiogenesis. Galectin-8 is markedly upregulated in inflamed human and mouse corneas, and galectin-8 inhibitors reduce inflammat...

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Bibliographic Details
Main Authors: Chen, Wei-Sheng, Cao, Zhiyi, Sugaya, Satoshi, Lopez, Maria J., Sendra, Victor G., Laver, Nora, Leffler, Hakon, Nilsson, Ulf J., Fu, Jianxin, Song, Jianhua, Xia, Lijun, Hamrah, Pedram, Panjwani, Noorjahan
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832077/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832077/

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