Overweight and obesity predict better overall survival rates in cancer patients with distant metastases

Recent studies conducted in patients with chronic diseases have reported an inverse association between body mass index (BMI) and mortality. However, the question as to whether BMI may predict prognosis in patients with metastatic cancer remains open. We therefore designed the current retrospective...

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Main Authors:	Tsang, Ngan Ming, Pai, Ping Ching, Chuang, Chi Cheng, Chuang, Wen Ching, Tseng, Chen Kan, Chang, Kai Ping, Yen, Tzu Chen, Lin, Jen Der, Chang, Joseph Tung Chieh
Format:	Online
Language:	English
Published:	John Wiley and Sons Inc. 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831285/

id	pubmed-4831285
recordtype	oai_dc
spelling	pubmed-48312852016-04-20 Overweight and obesity predict better overall survival rates in cancer patients with distant metastases Tsang, Ngan Ming Pai, Ping Ching Chuang, Chi Cheng Chuang, Wen Ching Tseng, Chen Kan Chang, Kai Ping Yen, Tzu Chen Lin, Jen Der Chang, Joseph Tung Chieh Clinical Cancer Research Recent studies conducted in patients with chronic diseases have reported an inverse association between body mass index (BMI) and mortality. However, the question as to whether BMI may predict prognosis in patients with metastatic cancer remains open. We therefore designed the current retrospective study to investigate the potential association between BMI and overall survival (OS) in patients with distant metastases (DM) and a favorable performance status. Between 2000 and 2012, a total of 4010 cancer patients with DM who required radiotherapy (RT) and had their BMI measured at the initiation of RT were identified. The relation between BMI and OS was examined by univariate and multivariable analysis. The median OS time was 3.23 months (range: 0.1–122.17) for underweight patients, 6.08 months (range: 0.03–149.46) for normal‐weight patients, 7.99 months (range: 0.07–158.01) for overweight patients, and 12.49 months (range, 0.2–164.1) for obese patients (log‐rank: P < 0.001). Compared with normal‐weight patients, both obese (HR = 0.676; 95% P < 0.001) and overweight individuals (HR = 0.84; P < 0.001) had a reduced risk of all‐cause mortality in multivariable analysis. Conversely, underweight patients had a significantly higher risk of death from all causes (HR = 1.41; P < 0.001). Overweight and obesity are independent predictors of better OS in metastatic patients with a good performance status. Increased BMI may play a role to identify metastatic patients with superior survival outcome and exhibit a potential to encourage aggressive management in those patients even with metastases. John Wiley and Sons Inc. 2016-01-26 /pmc/articles/PMC4831285/ /pubmed/26811258 http://dx.doi.org/10.1002/cam4.634 Text en © 2016 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Tsang, Ngan Ming Pai, Ping Ching Chuang, Chi Cheng Chuang, Wen Ching Tseng, Chen Kan Chang, Kai Ping Yen, Tzu Chen Lin, Jen Der Chang, Joseph Tung Chieh
spellingShingle	Tsang, Ngan Ming Pai, Ping Ching Chuang, Chi Cheng Chuang, Wen Ching Tseng, Chen Kan Chang, Kai Ping Yen, Tzu Chen Lin, Jen Der Chang, Joseph Tung Chieh Overweight and obesity predict better overall survival rates in cancer patients with distant metastases
author_facet	Tsang, Ngan Ming Pai, Ping Ching Chuang, Chi Cheng Chuang, Wen Ching Tseng, Chen Kan Chang, Kai Ping Yen, Tzu Chen Lin, Jen Der Chang, Joseph Tung Chieh
author_sort	Tsang, Ngan Ming
title	Overweight and obesity predict better overall survival rates in cancer patients with distant metastases
title_short	Overweight and obesity predict better overall survival rates in cancer patients with distant metastases
title_full	Overweight and obesity predict better overall survival rates in cancer patients with distant metastases
title_fullStr	Overweight and obesity predict better overall survival rates in cancer patients with distant metastases
title_full_unstemmed	Overweight and obesity predict better overall survival rates in cancer patients with distant metastases
title_sort	overweight and obesity predict better overall survival rates in cancer patients with distant metastases
description	Recent studies conducted in patients with chronic diseases have reported an inverse association between body mass index (BMI) and mortality. However, the question as to whether BMI may predict prognosis in patients with metastatic cancer remains open. We therefore designed the current retrospective study to investigate the potential association between BMI and overall survival (OS) in patients with distant metastases (DM) and a favorable performance status. Between 2000 and 2012, a total of 4010 cancer patients with DM who required radiotherapy (RT) and had their BMI measured at the initiation of RT were identified. The relation between BMI and OS was examined by univariate and multivariable analysis. The median OS time was 3.23 months (range: 0.1–122.17) for underweight patients, 6.08 months (range: 0.03–149.46) for normal‐weight patients, 7.99 months (range: 0.07–158.01) for overweight patients, and 12.49 months (range, 0.2–164.1) for obese patients (log‐rank: P < 0.001). Compared with normal‐weight patients, both obese (HR = 0.676; 95% P < 0.001) and overweight individuals (HR = 0.84; P < 0.001) had a reduced risk of all‐cause mortality in multivariable analysis. Conversely, underweight patients had a significantly higher risk of death from all causes (HR = 1.41; P < 0.001). Overweight and obesity are independent predictors of better OS in metastatic patients with a good performance status. Increased BMI may play a role to identify metastatic patients with superior survival outcome and exhibit a potential to encourage aggressive management in those patients even with metastases.
publisher	John Wiley and Sons Inc.
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831285/
_version_	1613566160505143296

Overweight and obesity predict better overall survival rates in cancer patients with distant metastases

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