Bidirectional Modulation of Numerical Magnitude

Numerical cognition is critical for modern life; however, the precise neural mechanisms underpinning numerical magnitude allocation in humans remain obscure. Based upon previous reports demonstrating the close behavioral and neuro-anatomical relationship between number allocation and spatial attenti...

Full description

Bibliographic Details
Main Authors:	Arshad, Qadeer, Nigmatullina, Yuliya, Nigmatullin, Ramil, Asavarut, Paladd, Goga, Usman, Khan, Sarah, Sander, Kaija, Siddiqui, Shuaib, Roberts, R. E., Cohen Kadosh, Roi, Bronstein, Adolfo M., Malhotra, Paresh A.
Format:	Online
Language:	English
Published:	Oxford University Press 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830300/

id	pubmed-4830300
recordtype	oai_dc
spelling	pubmed-48303002016-04-14 Bidirectional Modulation of Numerical Magnitude Arshad, Qadeer Nigmatullina, Yuliya Nigmatullin, Ramil Asavarut, Paladd Goga, Usman Khan, Sarah Sander, Kaija Siddiqui, Shuaib Roberts, R. E. Cohen Kadosh, Roi Bronstein, Adolfo M. Malhotra, Paresh A. Articles Numerical cognition is critical for modern life; however, the precise neural mechanisms underpinning numerical magnitude allocation in humans remain obscure. Based upon previous reports demonstrating the close behavioral and neuro-anatomical relationship between number allocation and spatial attention, we hypothesized that these systems would be subject to similar control mechanisms, namely dynamic interhemispheric competition. We employed a physiological paradigm, combining visual and vestibular stimulation, to induce interhemispheric conflict and subsequent unihemispheric inhibition, as confirmed by transcranial direct current stimulation (tDCS). This allowed us to demonstrate the first systematic bidirectional modulation of numerical magnitude toward either higher or lower numbers, independently of either eye movements or spatial attention mediated biases. We incorporated both our findings and those from the most widely accepted theoretical framework for numerical cognition to present a novel unifying computational model that describes how numerical magnitude allocation is subject to dynamic interhemispheric competition. That is, numerical allocation is continually updated in a contextual manner based upon relative magnitude, with the right hemisphere responsible for smaller magnitudes and the left hemisphere for larger magnitudes. Oxford University Press 2016-05 2016-02-14 /pmc/articles/PMC4830300/ /pubmed/26879093 http://dx.doi.org/10.1093/cercor/bhv344 Text en © The Author 2016. Published by Oxford University Press. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Arshad, Qadeer Nigmatullina, Yuliya Nigmatullin, Ramil Asavarut, Paladd Goga, Usman Khan, Sarah Sander, Kaija Siddiqui, Shuaib Roberts, R. E. Cohen Kadosh, Roi Bronstein, Adolfo M. Malhotra, Paresh A.
spellingShingle	Arshad, Qadeer Nigmatullina, Yuliya Nigmatullin, Ramil Asavarut, Paladd Goga, Usman Khan, Sarah Sander, Kaija Siddiqui, Shuaib Roberts, R. E. Cohen Kadosh, Roi Bronstein, Adolfo M. Malhotra, Paresh A. Bidirectional Modulation of Numerical Magnitude
author_facet	Arshad, Qadeer Nigmatullina, Yuliya Nigmatullin, Ramil Asavarut, Paladd Goga, Usman Khan, Sarah Sander, Kaija Siddiqui, Shuaib Roberts, R. E. Cohen Kadosh, Roi Bronstein, Adolfo M. Malhotra, Paresh A.
author_sort	Arshad, Qadeer
title	Bidirectional Modulation of Numerical Magnitude
title_short	Bidirectional Modulation of Numerical Magnitude
title_full	Bidirectional Modulation of Numerical Magnitude
title_fullStr	Bidirectional Modulation of Numerical Magnitude
title_full_unstemmed	Bidirectional Modulation of Numerical Magnitude
title_sort	bidirectional modulation of numerical magnitude
description	Numerical cognition is critical for modern life; however, the precise neural mechanisms underpinning numerical magnitude allocation in humans remain obscure. Based upon previous reports demonstrating the close behavioral and neuro-anatomical relationship between number allocation and spatial attention, we hypothesized that these systems would be subject to similar control mechanisms, namely dynamic interhemispheric competition. We employed a physiological paradigm, combining visual and vestibular stimulation, to induce interhemispheric conflict and subsequent unihemispheric inhibition, as confirmed by transcranial direct current stimulation (tDCS). This allowed us to demonstrate the first systematic bidirectional modulation of numerical magnitude toward either higher or lower numbers, independently of either eye movements or spatial attention mediated biases. We incorporated both our findings and those from the most widely accepted theoretical framework for numerical cognition to present a novel unifying computational model that describes how numerical magnitude allocation is subject to dynamic interhemispheric competition. That is, numerical allocation is continually updated in a contextual manner based upon relative magnitude, with the right hemisphere responsible for smaller magnitudes and the left hemisphere for larger magnitudes.
publisher	Oxford University Press
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830300/
_version_	1613565739435819008

Bidirectional Modulation of Numerical Magnitude

Similar Items