Astrocytes contribute to synapse elimination via type 2 inositol 1,4,5-trisphosphate receptor-dependent release of ATP

Astrocytes contribute to synapse elimination via type 2 inositol 1,4,5-trisphosphate receptor-dependent release of ATP

Selective elimination of unwanted synapses is vital for the precise formation of neuronal circuits during development, but the underlying mechanisms remain unclear. Using inositol 1,4,5-trisphosphate receptor type 2 knockout (Itpr2−/−) mice to specifically disturb somatic Ca2+ signaling in astrocyte...

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Bibliographic Details
Main Authors: Yang, Junhua, Yang, Hongbin, Liu, Yali, Li, Xia, Qin, Liming, Lou, Huifang, Duan, Shumin, Wang, Hao
Format: Online
Language:English
Published: eLife Sciences Publications, Ltd 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829431/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829431/

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