Myristic acid hitchhiking on sigma-1 receptor to fend off neurodegeneration
Neurodegenerative diseases are linked to tauopathy as a result of cyclin dependent kinase 5 (cdk5) binding to its p25 activator instead of its p35 activator and becoming over-activated. The overactive complex stimulates the hyperphosphorylation of tau proteins, leading to neurofibrillary tangles (NF...
| Main Authors: | , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
2016
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827442/ |