High magnetic field induced otolith fusion in the zebrafish larvae

Magnetoreception in animals illustrates the interaction of biological systems with the geomagnetic field (geoMF). However, there are few studies that identified the impact of high magnetic field (MF) exposure from Magnetic Resonance Imaging (MRI) scanners (>100,000 times of geoMF) on specific bio...

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Main Authors:	Pais-Roldán, Patricia, Singh, Ajeet Pratap, Schulz, Hildegard, Yu, Xin
Format:	Online
Language:	English
Published:	Nature Publishing Group 2016
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827070/

id	pubmed-4827070
recordtype	oai_dc
spelling	pubmed-48270702016-04-19 High magnetic field induced otolith fusion in the zebrafish larvae Pais-Roldán, Patricia Singh, Ajeet Pratap Schulz, Hildegard Yu, Xin Article Magnetoreception in animals illustrates the interaction of biological systems with the geomagnetic field (geoMF). However, there are few studies that identified the impact of high magnetic field (MF) exposure from Magnetic Resonance Imaging (MRI) scanners (>100,000 times of geoMF) on specific biological targets. Here, we investigated the effects of a 14 Tesla MRI scanner on zebrafish larvae. All zebrafish larvae aligned parallel to the B0 field, i.e. the static MF, in the MRI scanner. The two otoliths (ear stones) in the otic vesicles of zebrafish larvae older than 24 hours post fertilization (hpf) fused together after the high MF exposure as short as 2 hours, yielding a single-otolith phenotype with aberrant swimming behavior. The otolith fusion was blocked in zebrafish larvae under anesthesia or embedded in agarose. Hair cells may play an important role on the MF-induced otolith fusion. This work provided direct evidence to show that high MF interacts with the otic vesicle of zebrafish larvae and causes otolith fusion in an “all-or-none” manner. The MF-induced otolith fusion may facilitate the searching for MF sensors using genetically amenable vertebrate animal models, such as zebrafish. Nature Publishing Group 2016-04-11 /pmc/articles/PMC4827070/ /pubmed/27063288 http://dx.doi.org/10.1038/srep24151 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Pais-Roldán, Patricia Singh, Ajeet Pratap Schulz, Hildegard Yu, Xin
spellingShingle	Pais-Roldán, Patricia Singh, Ajeet Pratap Schulz, Hildegard Yu, Xin High magnetic field induced otolith fusion in the zebrafish larvae
author_facet	Pais-Roldán, Patricia Singh, Ajeet Pratap Schulz, Hildegard Yu, Xin
author_sort	Pais-Roldán, Patricia
title	High magnetic field induced otolith fusion in the zebrafish larvae
title_short	High magnetic field induced otolith fusion in the zebrafish larvae
title_full	High magnetic field induced otolith fusion in the zebrafish larvae
title_fullStr	High magnetic field induced otolith fusion in the zebrafish larvae
title_full_unstemmed	High magnetic field induced otolith fusion in the zebrafish larvae
title_sort	high magnetic field induced otolith fusion in the zebrafish larvae
description	Magnetoreception in animals illustrates the interaction of biological systems with the geomagnetic field (geoMF). However, there are few studies that identified the impact of high magnetic field (MF) exposure from Magnetic Resonance Imaging (MRI) scanners (>100,000 times of geoMF) on specific biological targets. Here, we investigated the effects of a 14 Tesla MRI scanner on zebrafish larvae. All zebrafish larvae aligned parallel to the B0 field, i.e. the static MF, in the MRI scanner. The two otoliths (ear stones) in the otic vesicles of zebrafish larvae older than 24 hours post fertilization (hpf) fused together after the high MF exposure as short as 2 hours, yielding a single-otolith phenotype with aberrant swimming behavior. The otolith fusion was blocked in zebrafish larvae under anesthesia or embedded in agarose. Hair cells may play an important role on the MF-induced otolith fusion. This work provided direct evidence to show that high MF interacts with the otic vesicle of zebrafish larvae and causes otolith fusion in an “all-or-none” manner. The MF-induced otolith fusion may facilitate the searching for MF sensors using genetically amenable vertebrate animal models, such as zebrafish.
publisher	Nature Publishing Group
publishDate	2016
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827070/
_version_	1613564541743923200

High magnetic field induced otolith fusion in the zebrafish larvae

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