Non-Linear and Flexible Regions of the Human Notch1 Extracellular Domain Revealed by High-Resolution Structural Studies
The Notch receptor is a key component of a core metazoan signaling pathway activated by Delta/Serrate/Lag-2 ligands expressed on an adjacent cell. This results in a short-range signal with profound effects on cell-fate determination, cell proliferation, and cell death. Key to understanding receptor...
| Main Authors: | , , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Cell Press
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826273/ |