Robust classification of protein variation using structural modelling and large-scale data integration

Existing methods for interpreting protein variation focus on annotating mutation pathogenicity rather than detailed interpretation of variant deleteriousness and frequently use only sequence-based or structure-based information. We present VIPUR, a computational framework that seamlessly integrates...

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Bibliographic Details
Main Authors: Baugh, Evan H., Simmons-Edler, Riley, Müller, Christian L., Alford, Rebecca F., Volfovsky, Natalia, Lash, Alex E., Bonneau, Richard
Format: Online
Language:English
Published: Oxford University Press 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824117/