Chromosome-wide histone deacetylation by sirtuins prevents hyperactivation of DNA damage-induced signaling upon replicative stress

Chromosome-wide histone deacetylation by sirtuins prevents hyperactivation of DNA damage-induced signaling upon replicative stress

The Saccharomyces cerevisiae genome encodes five sirtuins (Sir2 and Hst1–4), which constitute a conserved family of NAD-dependent histone deacetylases. Cells lacking any individual sirtuin display mild growth and gene silencing defects. However, hst3Δ hst4Δ double mutants are exquisitely sensitive t...

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Bibliographic Details
Main Authors: Simoneau, Antoine, Ricard, Étienne, Weber, Sandra, Hammond-Martel, Ian, Wong, Lai Hong, Sellam, Adnane, Giaever, Guri, Nislow, Corey, Raymond, Martine, Wurtele, Hugo
Format: Online
Language:English
Published: Oxford University Press 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824096/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824096/

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