Non-canonical uracil processing in DNA gives rise to double-strand breaks and deletions: relevance to class switch recombination

Non-canonical uracil processing in DNA gives rise to double-strand breaks and deletions: relevance to class switch recombination

During class switch recombination (CSR), antigen-stimulated B-cells rearrange their immunoglobulin constant heavy chain (CH) loci to generate antibodies with different effector functions. CSR is initiated by activation-induced deaminase (AID), which converts cytosines in switch (S) regions, repetiti...

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Bibliographic Details
Main Authors: Bregenhorn, Stephanie, Kallenberger, Lia, Artola-Borán, Mariela, Peña-Diaz, Javier, Jiricny, Josef
Format: Online
Language:English
Published: Oxford University Press 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824095/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824095/

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