Chemo-enzymatic synthesis of site-specific isotopically labeled nucleotides for use in NMR resonance assignment, dynamics and structural characterizations

Chemo-enzymatic synthesis of site-specific isotopically labeled nucleotides for use in NMR resonance assignment, dynamics and structural characterizations

Stable isotope labeling is central to NMR studies of nucleic acids. Development of methods that incorporate labels at specific atomic positions within each nucleotide promises to expand the size range of RNAs that can be studied by NMR. Using recombinantly expressed enzymes and chemically synthesize...

Full description

Bibliographic Details
Main Authors: Longhini, Andrew P., LeBlanc, Regan M., Becette, Owen, Salguero, Carolina, Wunderlich, Christoph H., Johnson, Bruce A., D'Souza, Victoria M., Kreutz, Christoph, Dayie, T. Kwaku
Format: Online
Language:English
Published: Oxford University Press 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824079/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824079/

Similar Items