Growth hormone (GH)‐transgenic insulin‐like growth factor 1 (IGF1)‐deficient mice allow dissociation of excess GH and IGF1 effects on glomerular and tubular growth
Growth hormone (GH)‐transgenic mice with permanently elevated systemic levels of GH and insulin‐like growth factor 1 (IGF1) reproducibly develop renal and glomerular hypertrophy and subsequent progressive glomerulosclerosis, finally leading to terminal renal failure. To dissociate IGF1‐dependent and...
Main Authors: | , , , |
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Format: | Online |
Language: | English |
Published: |
John Wiley and Sons Inc.
2016
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Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823598/ |