Mutational landscape of MCPyV-positive and MCPyV-negative Merkel cell carcinomas with implications for immunotherapy

Mutational landscape of MCPyV-positive and MCPyV-negative Merkel cell carcinomas with implications for immunotherapy

Merkel cell carcinoma (MCC) is a rare but highly aggressive cutaneous neuroendocrine carcinoma, associated with the Merkel cell polyomavirus (MCPyV) in 80% of cases. To define the genetic basis of MCCs, we performed exome sequencing of 49 MCCs. We show that MCPyV-negative MCCs have a high mutation b...

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Bibliographic Details
Main Authors: Goh, Gerald, Walradt, Trent, Markarov, Vladimir, Blom, Astrid, Riaz, Nadeem, Doumani, Ryan, Stafstrom, Krista, Moshiri, Ata, Yelistratova, Lola, Levinsohn, Jonathan, Chan, Timothy A., Nghiem, Paul, Lifton, Richard P., Choi, Jaehyuk
Format: Online
Language:English
Published: Impact Journals LLC 2015
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823115/

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