Combined approaches of EPR and NMR illustrate only one transmembrane helix in the human IFITM3

Interferon-inducible transmembrane protein IFITM3 was known to restrict the entry of a wide spectrum of viruses to the cytosol of the host. The mechanism used by the protein to restrict viral entry is unclear given the unavailability of the membrane topology and structures of the IFITM family protei...

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Bibliographic Details
Main Authors: Ling, Shenglong, Zhang, Chengwei, Wang, Wei, Cai, Xiaoying, Yu, Lu, Wu, Fangming, Zhang, Longhua, Tian, Changlin
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820770/