Regnase-1 in microglia negatively regulates high mobility group box 1-mediated inflammation and neuronal injury

Extracellular high mobility group box 1 (HMGB1) has been demonstrated to function as a proinflammatory cytokine and induces neuronal injury in response to various pathological stimuli in central nervous system (CNS). However, the regulatory factor involved in HMGB1-mediated inflammatory signaling is...

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Bibliographic Details
Main Authors: Liu, Xiao-Xi, Wang, Chen, Huang, Shao-Fei, Chen, Qiong, Hu, Ya-Fang, Zhou, Liang, Gu, Yong
Format: Online
Language:English
Published: Nature Publishing Group 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820713/