Regulation of protein-ligand binding affinity by hydrogen bond pairing

Receptor-ligand H-bond pairings have evolved to promote high-affinity binding by reducing competitive interference with water.

Bibliographic Details
Main Authors: Chen, Deliang, Oezguen, Numan, Urvil, Petri, Ferguson, Colin, Dann, Sara M., Savidge, Tor C.
Format: Online
Language:English
Published: American Association for the Advancement of Science 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820369/