The potential of lipocalin-2/NGAL as biomarker for inflammatory and metabolic diseases
Lipocalin-2 (LCN2), also known as neutrophil gelatinase-associated lipocalin (NGAL), is a secreted glycoprotein that belongs to a group of transporters of small lipophilic molecules in circulation. LCN2 has been recently characterized as an adipose-derived cytokine. This adipokine is believed to bin...
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| Format: | Online |
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Taylor & Francis
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819811/ |
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pubmed-4819811 |
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pubmed-48198112016-04-22 The potential of lipocalin-2/NGAL as biomarker for inflammatory and metabolic diseases Abella, Vanessa Scotece, Morena Conde, Javier Gómez, Rodolfo Lois, Ana Pino, Jesús Gómez-Reino, Juan J. Lago, Francisca Mobasheri, Ali Gualillo, Oreste Research Article Lipocalin-2 (LCN2), also known as neutrophil gelatinase-associated lipocalin (NGAL), is a secreted glycoprotein that belongs to a group of transporters of small lipophilic molecules in circulation. LCN2 has been recently characterized as an adipose-derived cytokine. This adipokine is believed to bind small substances, such as steroids and lipopolysaccharides, and has been reported to have roles in the induction of apoptosis in hematopoietic cells, transport of fatty acids and iron, modulation of inflammation, and metabolic homeostasis. Recently, LCN2 has emerged as a useful biomarker and rheumatic diseases. This review provides an overview of LCN2 in inflammation, immunity, and metabolism. Taylor & Francis 2015-11-17 2015-12-15 /pmc/articles/PMC4819811/ /pubmed/26671823 http://dx.doi.org/10.3109/1354750X.2015.1123354 Text en © 2015 The Author(s). Published by Taylor & Francis. http://creativecommons.org/Licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/Licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, orbuilt upon in any way. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Abella, Vanessa Scotece, Morena Conde, Javier Gómez, Rodolfo Lois, Ana Pino, Jesús Gómez-Reino, Juan J. Lago, Francisca Mobasheri, Ali Gualillo, Oreste |
| spellingShingle |
Abella, Vanessa Scotece, Morena Conde, Javier Gómez, Rodolfo Lois, Ana Pino, Jesús Gómez-Reino, Juan J. Lago, Francisca Mobasheri, Ali Gualillo, Oreste The potential of lipocalin-2/NGAL as biomarker for inflammatory and metabolic diseases |
| author_facet |
Abella, Vanessa Scotece, Morena Conde, Javier Gómez, Rodolfo Lois, Ana Pino, Jesús Gómez-Reino, Juan J. Lago, Francisca Mobasheri, Ali Gualillo, Oreste |
| author_sort |
Abella, Vanessa |
| title |
The potential of lipocalin-2/NGAL as biomarker for inflammatory and metabolic diseases |
| title_short |
The potential of lipocalin-2/NGAL as biomarker for inflammatory and metabolic diseases |
| title_full |
The potential of lipocalin-2/NGAL as biomarker for inflammatory and metabolic diseases |
| title_fullStr |
The potential of lipocalin-2/NGAL as biomarker for inflammatory and metabolic diseases |
| title_full_unstemmed |
The potential of lipocalin-2/NGAL as biomarker for inflammatory and metabolic diseases |
| title_sort |
potential of lipocalin-2/ngal as biomarker for inflammatory and metabolic diseases |
| description |
Lipocalin-2 (LCN2), also known as neutrophil gelatinase-associated lipocalin (NGAL), is a secreted glycoprotein that belongs to a group of transporters of small lipophilic molecules in circulation. LCN2 has been recently characterized as an adipose-derived cytokine. This adipokine is believed to bind small substances, such as steroids and lipopolysaccharides, and has been reported to have roles in the induction of apoptosis in hematopoietic cells, transport of fatty acids and iron, modulation of inflammation, and metabolic homeostasis. Recently, LCN2 has emerged as a useful biomarker and rheumatic diseases. This review provides an overview of LCN2 in inflammation, immunity, and metabolism. |
| publisher |
Taylor & Francis |
| publishDate |
2015 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819811/ |
| _version_ |
1613561830755532800 |