Lysosomal Disorders Drive Susceptibility to Tuberculosis by Compromising Macrophage Migration

Lysosomal Disorders Drive Susceptibility to Tuberculosis by Compromising Macrophage Migration

A zebrafish genetic screen for determinants of susceptibility to Mycobacterium marinum identified a hypersusceptible mutant deficient in lysosomal cysteine cathepsins that manifests hallmarks of human lysosomal storage diseases. Under homeostatic conditions, mutant macrophages accumulate undigested...

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Bibliographic Details
Main Authors: Berg, Russell D., Levitte, Steven, O’Sullivan, Mary P., O’Leary, Seónadh M., Cambier, C.J., Cameron, James, Takaki, Kevin K., Moens, Cecilia B., Tobin, David M., Keane, Joseph, Ramakrishnan, Lalita
Format: Online
Language:English
Published: Cell Press 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819607/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819607/

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