Evaluation of RNA Amplification Methods to Improve DC Immunotherapy Antigen Presentation and Immune Response

Dendritic cells (DCs) transfected with total amplified tumor cell RNA have the potential to induce broad antitumor immune responses. However, analytical methods required for quantitatively assessing the integrity, fidelity, and functionality of the amplified RNA are lacking. We have developed a seri...

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Bibliographic Details
Main Authors: Slagter-Jäger, Jacoba G, Raney, Alexa, Lewis, Whitney E, DeBenedette, Mark A, Nicolette, Charles A, Tcherepanova, Irina Y
Format: Online
Language:English
Published: Nature Publishing Group 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817939/