siRNA Screen Identifies Trafficking Host Factors that Modulate Alphavirus Infection

siRNA Screen Identifies Trafficking Host Factors that Modulate Alphavirus Infection

Little is known about the repertoire of cellular factors involved in the replication of pathogenic alphaviruses. To uncover molecular regulators of alphavirus infection, and to identify candidate drug targets, we performed a high-content imaging-based siRNA screen. We revealed an actin-remodeling pa...

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Bibliographic Details
Main Authors: Radoshitzky, Sheli R., Pegoraro, Gianluca, Chī, Xiǎolì, Dǒng, Lián, Chiang, Chih-Yuan, Jozwick, Lucas, Clester, Jeremiah C., Cooper, Christopher L., Courier, Duane, Langan, David P., Underwood, Knashka, Kuehl, Kathleen A., Sun, Mei G., Caì, Yíngyún, Yú, Shuǐqìng, Burk, Robin, Zamani, Rouzbeh, Kota, Krishna, Kuhn, Jens H., Bavari, Sina
Format: Online
Language:English
Published: Public Library of Science 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816540/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816540/

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