Mitochondria in White, Brown, and Beige Adipocytes

Mitochondria in White, Brown, and Beige Adipocytes

Mitochondria play a key role in energy metabolism in many tissues, including cardiac and skeletal muscle, brain, liver, and adipose tissue. Three types of adipose depots can be identified in mammals, commonly classified according to their colour appearance: the white (WAT), the brown (BAT), and the...

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Main Authors: Cedikova, Miroslava, Kripnerová, Michaela, Dvorakova, Jana, Pitule, Pavel, Grundmanova, Martina, Babuska, Vaclav, Mullerova, Dana, Kuncova, Jitka
Format: Online
Language:English
Published: Hindawi Publishing Corporation 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814709/
id pubmed-4814709
recordtype oai_dc
spelling pubmed-48147092016-04-12 Mitochondria in White, Brown, and Beige Adipocytes Cedikova, Miroslava Kripnerová, Michaela Dvorakova, Jana Pitule, Pavel Grundmanova, Martina Babuska, Vaclav Mullerova, Dana Kuncova, Jitka Review Article Mitochondria play a key role in energy metabolism in many tissues, including cardiac and skeletal muscle, brain, liver, and adipose tissue. Three types of adipose depots can be identified in mammals, commonly classified according to their colour appearance: the white (WAT), the brown (BAT), and the beige/brite/brown-like (bAT) adipose tissues. WAT is mainly involved in the storage and mobilization of energy and BAT is predominantly responsible for nonshivering thermogenesis. Recent data suggest that adipocyte mitochondria might play an important role in the development of obesity through defects in mitochondrial lipogenesis and lipolysis, regulation of adipocyte differentiation, apoptosis, production of oxygen radicals, efficiency of oxidative phosphorylation, and regulation of conversion of white adipocytes into brown-like adipocytes. This review summarizes the main characteristics of each adipose tissue subtype and describes morphological and functional modifications focusing on mitochondria and their activity in healthy and unhealthy adipocytes. Hindawi Publishing Corporation 2016 2016-03-17 /pmc/articles/PMC4814709/ /pubmed/27073398 http://dx.doi.org/10.1155/2016/6067349 Text en Copyright © 2016 Miroslava Cedikova et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Cedikova, Miroslava
Kripnerová, Michaela
Dvorakova, Jana
Pitule, Pavel
Grundmanova, Martina
Babuska, Vaclav
Mullerova, Dana
Kuncova, Jitka
spellingShingle Cedikova, Miroslava
Kripnerová, Michaela
Dvorakova, Jana
Pitule, Pavel
Grundmanova, Martina
Babuska, Vaclav
Mullerova, Dana
Kuncova, Jitka
Mitochondria in White, Brown, and Beige Adipocytes
author_facet Cedikova, Miroslava
Kripnerová, Michaela
Dvorakova, Jana
Pitule, Pavel
Grundmanova, Martina
Babuska, Vaclav
Mullerova, Dana
Kuncova, Jitka
author_sort Cedikova, Miroslava
title Mitochondria in White, Brown, and Beige Adipocytes
title_short Mitochondria in White, Brown, and Beige Adipocytes
title_full Mitochondria in White, Brown, and Beige Adipocytes
title_fullStr Mitochondria in White, Brown, and Beige Adipocytes
title_full_unstemmed Mitochondria in White, Brown, and Beige Adipocytes
title_sort mitochondria in white, brown, and beige adipocytes
description Mitochondria play a key role in energy metabolism in many tissues, including cardiac and skeletal muscle, brain, liver, and adipose tissue. Three types of adipose depots can be identified in mammals, commonly classified according to their colour appearance: the white (WAT), the brown (BAT), and the beige/brite/brown-like (bAT) adipose tissues. WAT is mainly involved in the storage and mobilization of energy and BAT is predominantly responsible for nonshivering thermogenesis. Recent data suggest that adipocyte mitochondria might play an important role in the development of obesity through defects in mitochondrial lipogenesis and lipolysis, regulation of adipocyte differentiation, apoptosis, production of oxygen radicals, efficiency of oxidative phosphorylation, and regulation of conversion of white adipocytes into brown-like adipocytes. This review summarizes the main characteristics of each adipose tissue subtype and describes morphological and functional modifications focusing on mitochondria and their activity in healthy and unhealthy adipocytes.
publisher Hindawi Publishing Corporation
publishDate 2016
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814709/
_version_ 1613560059662434304

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