Protection against Mitochondrial and Metal Toxicity Depends on Functional Lipid Binding Sites in ATP13A2

Protection against Mitochondrial and Metal Toxicity Depends on Functional Lipid Binding Sites in ATP13A2

The late endo-/lysosomal P-type ATPase ATP13A2 (PARK9) is implicated in Parkinson's disease (PD) and Kufor-Rakeb syndrome, early-onset atypical Parkinsonism. ATP13A2 interacts at the N-terminus with the signaling lipids phosphatidic acid (PA) and phosphatidylinositol (3,5) bisphosphate (PI(3,5)...

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Bibliographic Details
Main Authors: Martin, Shaun, van Veen, Sarah, Holemans, Tine, Demirsoy, Seyma, van den Haute, Chris, Baekelandt, Veerle, Agostinis, Patrizia, Eggermont, Jan, Vangheluwe, Peter
Format: Online
Language:English
Published: Hindawi Publishing Corporation 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814700/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814700/

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