Microbial sphingomyelinase induces RhoA-mediated reorganization of the apical brush border membrane and is protective against invasion
Both commensal and pathogenic microbes that colonize the GI tract can synthesize and secrete spingomyelinase enzymes that cleave membrane sphingomyelin, leaving the ceramide component intact in the cell membrane. This study examines how this reaction affects the structure and function of host entero...
| Main Authors: | , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
The American Society for Cell Biology
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814219/ |