β-Subunit Binding Is Sufficient for Ligands to Open the Integrin αIIbβ3 Headpiece*
The platelet integrin αIIbβ3 binds to a KQAGDV motif at the fibrinogen γ-chain C terminus and to RGD motifs present in loops in many extracellular matrix proteins. These ligands bind in a groove between the integrin α and β-subunits; the basic Lys or Arg side chain hydrogen bonds to the αIIb-subunit...
| Main Authors: | , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
American Society for Biochemistry and Molecular Biology
2016
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813479/ |