BRCA somatic and germline mutation detection in paraffin embedded ovarian cancers by next-generation sequencing

BRCA somatic and germline mutation detection in paraffin embedded ovarian cancers by next-generation sequencing

BRCA mutated ovarian cancers respond better to platinum-based therapy and to the recently approved PARP-inhibitors. There is the need for efficient and timely methods to detect both somatic and germline mutations using formalin-fixed paraffin-embedded (FFPE) tissues and commercially available techno...

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Bibliographic Details
Main Authors: Mafficini, Andrea, Simbolo, Michele, Parisi, Alice, Rusev, Borislav, Luchini, Claudio, Cataldo, Ivana, Piazzola, Elena, Sperandio, Nicola, Turri, Giona, Franchi, Massimo, Tortora, Giampaolo, Bovo, Chiara, Lawlor, Rita T., Scarpa, Aldo
Format: Online
Language:English
Published: Impact Journals LLC 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811444/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811444/

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