PRIMA-1MET induces apoptosis through accumulation of intracellular reactive oxygen species irrespective of p53 status and chemo-sensitivity in epithelial ovarian cancer cells

PRIMA-1MET induces apoptosis through accumulation of intracellular reactive oxygen species irrespective of p53 status and chemo-sensitivity in epithelial ovarian cancer cells

There is an intensive need for the development of novel drugs for the treatment of epithelial ovarian cancer (EOC), the most lethal gynecologic malignancy due to the high recurrence rate. TP53 mutation is a common event in EOC, particularly in high-grade serous ovarian cancer, where it occurs in mor...

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Bibliographic Details
Main Authors: YOSHIKAWA, NOBUHISA, KAJIYAMA, HIROAKI, NAKAMURA, KAE, UTSUMI, FUMI, NIIMI, KAORU, MITSUI, HIROKO, SEKIYA, RYUICHIRO, SUZUKI, SHIRO, SHIBATA, KIYOSUMI, CALLEN, DAVID, KIKKAWA, FUMITAKA
Format: Online
Language:English
Published: D.A. Spandidos 2016
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811399/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811399/

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